and so it goes… (went)
Muggleborn students at Hogwarts (part 1/?)
Bromeo and Dudeliet, a forbidden bromance between two bros in rival fraternities, in fair Vebrona where we lay our scene
Two frat houses, broth alike in dignity
in fair Verbrona where we lay our scene
From mancient grudge break to new dudetiny
Where civil blood makes civil mands unclean
WARFARIN-INDUCED SKIN NECROSIS
Warfarin necrosis usually occurs three to five days after drug therapy is begun, and a high initial dose increases the risk of its development.:122 Heparin-induced necrosis can develop both at sites of localinjection and - when infused intravenously - in a widespread pattern.:123
In warfarin’s initial stages of action, inhibition of protein C and Factor VII is stronger than inhibition of the other vitamin K-dependent coagulation factors II, IX and X. This results from the fact that these proteins have different half-lives: 1.5 to six hours for factor VII and eight hours for protein C, versus one day for factor IX, two days for factor X and two to five days for factor II. The larger the initial dose of vitamin K-antagonist, the more pronounced these differences are. This coagulation factor imbalance leads to paradoxical activation of coagulation, resulting in a hypercoagulable state and thrombosis. The blood clots interrupt the blood supply to the skin, causing necrosis. Protein C is an innate anticoagulant, and as warfarin further decreases protein C levels, it can lead to massive thrombosis with necrosis and gangrene of limbs.
Notably, the prothrombin time (or international normalized ratio, INR) used to test the effect of coumarins is highly dependent on factor VII, which explains why patients can have a therapeutic INR (indicating good anticoagulant effect) but still be in a hypercoagulable state.
In one third of cases, warfarin necrosis occurs in patients with an underlying, innate and previously unknown deficiency of protein C. The condition is related to purpura fulminans, a complication in infants with sepsis (blood stream infection) which also involves skin necrosis. These infants often have protein C deficiency as well. There have also been cases in patients with other deficiency, including protein S deficiency, activated protein C resistance (Factor V Leiden) and antithrombin III deficiency.
i love the Women Against Feminism that are like “I dont need feminism because i can admit i need my husband to open a jar for me and thats ok!” cause listen 1. get a towel 2. get the towel damp 3. put it on the lid and twist. BAM now men are completely useless. you, too, can open a jar. time to get a divorce
love turns to a s h e s
with all that I wish I could say
LOL I love when Stiles is a smartass
That SMILE though
It’s okay, Lydia. You can have one extra hour in the ball pit.
PARRISH WHO ARE YOU???